| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Antimicrobial PEGtides: A Modular Poly(ethylene glycol)-Based Peptidomimetic Approach to Combat Bacteria |
| 초록 |
Despite their high potency, the widespread implementation of natural antimicrobial peptides is still challenging due to their low scalability and high hemolytic activities. Herein, we address these issues by employing a modular approach to mimic the key amino acid residues present in antimicrobial peptides, such as lysine, leucine, and serine, but on the highly biocompatible poly(ethylene glycol) (PEG)backbone. A series of these PEG-based peptides (PEGtides)were developed using functional epoxide monomers, corresponding to each key amino acid, with several possessing highly potent bactericidal activities and controlled selectivities, with respect to their hemolytic behavior. The critical role of the composition and the structure of the PEGtides in their selectivities was further supported by coarse-grained molecular dynamic simulations. This modular approach is anticipated to provide the design principles necessary for the future development of antimicrobial polymers. |
| 저자 |
김민성1, 문원식1, 정우혁2, 이준희3, 조가영1, 권지수1, 안동준2, Robert J. Mitchell1, 김병수3
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| 소속 |
1울산과학기술원, 2고려대, 3연세대 |
| 키워드 |
polymeric antimicrobials; polyethers; functional epoxide monomer; peptidomimetics; molecular dynamic simulation
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| E-Mail |
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