| 학회 |
한국고분자학회 |
| 학술대회 |
2022년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
47권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Cryopreserved Cell Viability Using Functionalized 2D Nanostructures with Anti-Freezing Activity |
| 초록 |
As interest in cryogenic cold chains of medicines increases, the importance of cryopreservation of biological samples is being emphasized. In order to help the cells to survive after freezing-and-thawing cycle, cryoprotectant agents (CPAs) are commonly introduced to cell media. In this study, we demonstrate that self-assembled nanostructures have substantial ability to protect cells undergoing ice formation and growth, thereby can be utilized as a CPA as their nanoscale morphology and ice-philic function are tailored. The main goal of this research is to innovate the anti-freezing nanomaterials by benefitting from the recent advances of structural nanotechnology. The 2-dimensinal nanostructures are biocompatible materials that compensates for the drawbacks of existing chemical cryoprotectants. As a result of observing ice formation and recrystallization inside living cells, it was confirmed that 2-dimensinal nanostructures prevent cell damage and increase cell viability by preventing ice recrystallization. |
| 저자 |
이예담1, 이찬석2, 정우혁1, 김도년2, 안동준1
|
| 소속 |
1고려대, 2서울대 |
| 키워드 |
- |
| E-Mail |
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