| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Bioreducible Crosslinked Hyaluronic Acid Nanoparticles for Targeted Cancer Therapy and Imaging |
| 초록 |
Self-assembled polymeric nanoparticles with high in vivo stability and tumor-targeting ability have been developed as drug carriers for improved therapeutic efficacy. In this study, we developed bioreducible core-crosslinked hyaluronic acid nanoparticles (HANPs) by a facile method in aqueous conditions. The resulting nanoparticles (CC-HANPs) were smaller in size than HANPs owing to the formation of a compact core-cross-link. The CC-HANPs exhibited enhanced structural stability under diluted condition with PBS containing FBS and sodium dodecyl sulfates (SDS). In particular, the drug release rate of CC-HANPs was rapidly accelerated in the presence of 10mM GSH, whereas the drug release was significantly retarded in physiological buffer (pH 7.4). Overall, these results suggest that bioreducible CC-HANPs could be applied as a targeted doxorubicin delivery carrier for cancer therapy and imaging. |
| 저자 |
한화승1, 고혜원1, 안재윤1, 이민창2, 박재형1
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| 소속 |
1성균관대, 2가천대 |
| 키워드 |
Hyaluronic Acid; Nanoparticles; Drug Delivery
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| E-Mail |
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