| 학회 |
한국화학공학회 |
| 학술대회 |
2007년 봄 (04/19 ~ 04/20, 울산 롯데호텔) |
| 권호 |
13권 1호, p.399 |
| 발표분야 |
생물화공 |
| 제목 |
A composite scaffold composed of collagen nano-fiber on amniotic membrane for bioartificial periodontal ligament |
| 초록 |
Various biodegradable scaffolds have been used for the development of bioartificial periodontal ligament (Bio-PDL), but those scaffolds were focused on cell growth and differentiation only, and could not function as guided tissue regeneration (GTR) membrane which can inhibit gingival cells migration. So, in this study we tried to make a composite scaffold composed of collagen nano-fiber on amniotic membrane (AM) using electrospinning for dental tissue engineering. We could make a composite scaffold whose breaking load was 1 ± 0.3 N superior to nano-fiber scaffold without AM (0.1 ± 0.05 N). After seeding of PDL cell on each scaffold, they attached and proliferated well on both scaffolds. However nano-fiber scaffold without AM was contracted after 5 days of culture, but composite nano-fiber scaffold was not contracted during all culture days.Composite nano-fiber scaffold made by electrospinning collagen fiber on AM will be a suitable substrate for PDL cell culture finally resulting in a good Bio-PDL. |
| 저자 |
한미정1, 서영권1, 안재일1, 최경민1, 윤희훈1, 송계용2, 김영진3, 박정극1
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| 소속 |
1동국대, 2중앙대, 3라이프코드 |
| 키워드 |
composite nanofiber scaffold; amminotic membrane; bioartificial periodontal ligament; tissue engineering
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| E-Mail |
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| 원문파일 |
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