| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.463 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Transdermal Vaccine Delivery with Microneedle System |
| 초록 | The success of transdermal drug delivery has been severely limited by the inability of most drugs to enter the skin at therapeutically useful rates. Recently, the use of micron-scale needles in increasing skin permeability has been proposed and shown to dramatically increase transdermal delivery, especially for macromolecules.1,2 For these studies, needle arrays have been used to pierce holes into skin to increase transport by diffusion. (Table 1 and Figure 1) FITC-OVA as model drug has used of microneedle system for protein delivery. Microneedles inserted into the skin of human subjects were reported as painless. Together, these results suggest that microneedles represent a promising technology to deliver therapeutic compounds into the skin for a range of possible applications.3,4 The depth of skin penetration targets skin immune cells; the quantity of FITC-OVA delivered can be controlled by formulation, patch wearing time, and system size. This novel microneedle system technology may ultimately have broad applications for a wide variety of therapeutic vaccines to improve efficacy and convenience of use. Table 1. Specification of microneedle system. Figure 1. Picture of microneedle system used for transdermal drug delivery. Acknowledgment : This work was supported by KMOCIE References 1. M. R. Prausnitz, Adv. Drug Deliv. Rev., 56, 581-587 (2004) 2. J. A. Matriano, M. Cormier, J. Johnson, W. A. Young, M. Buttery, K. Nyam and P. E. Daddona, Pharm. Res., 19, 63-70 (2002) 3. B. Barry and A. Williams, Adv. Drug Deliv. Rev., 56, 603-618 (2003) 4. G. Cevc, Adv. Drug Deliv. Rev., 56, 675-711 (2004) |
| 저자 | 장우영1, 최경수1, 이승현1, 엄성용2, 이한구2, 이종문1, 이해방3, 강길선1 |
| 소속 | 1전북대, 2대신제약, 3한국화학(연) |
| 키워드 | transdermal; vaccine; microneedle; FITC-OVA |
