| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Characterization and Biological Properties of Gellan Gum Hydrogel |
| 초록 |
Gellan gum (GG) is an exopolysaccharide produced by Sphingomonas elodea. In this study we prepared three dimensional hydrogel of GG reacted with 1-ethyl-3-(3-di-methylaminopropyl)carbodiimide (EDC) to obtain a cross-linked GG. From the FT-IR analy- sis, the mechanism of EDC cross-linking in the GG was the condensation reaction between the carboxyl and hydroxyl group. Because polysaccharide hydrogels normally possess poor mechanical strength, the results obtained in this study indicate that GG is sutiable for potential applications in tissue regeneration. In vitro biocompativility tests, hydrogel ex- hibited nontoxic effects. When implanted in to rat subcutaneous tissue, implantation showed that hydrogel caused slight inflammation in the first few days after operation. In the tissue engineering, cross-linked GG demonstrated good physical properties and biocompatibility, and has great potential for future use. This research was supported by WCU (R31-20029) and MBC (0405-BO01-0204-0006). |
| 저자 |
유한나, 김형은, 김하늘, 송정은, 송병주, 김영운, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
Gellan gum; Hydrogel; Biocompativility
|
| E-Mail |
|
