| 초록 |
Due to myocardial infarction, stenting is performed on the coronary arteries for therapeutic purposes. Recently, several trials have been reported to replace bare metal stents as biodegradable stents such as PLA, but bare metal stents are still used owing to the poor prognosis of biodegradable stents. However, in principle, bare metal stents also accompany inflammation and neointimal formation, and drugs have been coated on the bare metal stents suppress them. In this study, hydrogel nano/microfibers containing hyaluronic acid, a biodegradable natural polymer, were coated on the bare metal stent for suppressing thrombosis, preventing unwanted cell adhesion, and trying to avoid neointimal hyperplasia. In addition, we tried to measure the therapeutic effect of drug release by mixing methotrexate, an anti-inflammatory drug, into hydrogel nano/micro fibers. Potentially this hydrogel-fiber coated stent can be therapeutic biomedical device for cardiovascular diseases. |
