| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 | 27권 2호, p.183 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Preparation and In Vitro Evaluation of Solidified-Emulsion by Cationic Lipid |
| 초록 | In this study, the drug release pattern and loading efficiency were examined by cationic lipid ratio. Solidified-emulsion containing a drug substance was prepared by crosslinking liquid emulsion mixtures containing sodium alginate and other excipients (hydroxypropyl methylcellulose, starch, etc.). The mixtures were dropped into the aqueous solution containing calcium chloride as crosslinker. Obtained solidified-emulsion washed with the distilled water to remove the unreacted calcium chloride and the washed solidified-emulsion beads were freeze-dried for 48h. The containing emulsion, product readily redispersed in proper media without re-aggregation because of containing prepared emulsion by self-emulsifying system. Oil droplet size of redispersed solidified-emulsion in media was reconstituted the smaller droplet size than the initial size. The drug content of beads increased with increasing cationic lipid content, alginate content as well as the washing time at constant other contents. This system had several advantages of with ease storage and predictability of drug release rate and may be useful as an oral administration dosage form. Acknowledgment: This work was supported by KMOHW (Grant No.; HMP-98-G-2-051-B). |
| 저자 | 윤복영1, 서선아*2, 강복기*3, 정상영**, 강길선, 이해방**, 조선행** |
| 소속 | 1전북대, 2*전북대, 3**한국화학(연) |
| 키워드 | solidified; emulsion; cationic; lipid |
