| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Temperature-responsive drug release behavior of surface modified PVA/PNIPAAm hydrogel |
| 초록 |
The poly(vinyl alcohol)/ poly(N-isopropylacrylamide) hydrogel was synthesized by the free radical polymerization for the temperature-responsive drug delivery carrier. The oxyfluorination and fluorination of the hydrogel have a pronounced effect on the drug release behavior resulting from the introduction of C-O bonds or C-F bonds. The oxyfluorination and fluorination treatments changed the surface characteristics to have hydrophilic functional groups and hydrophobic functional groups, respectively. Both swelling ratio and drug release behavior were remarkably improved on the oxyfluorination conditions as more hydrophilic functional groups were introduced. On the other hand, drug release from fluorinated hydrogel showed the sustained drug release behavior compared to the oxyfluorinated hydrogel. |
| 저자 |
김연이, 윤주미, 김형일
|
| 소속 |
충남대 |
| 키워드 |
Temperature-responsive drug release; oxyfluorination; fluorination
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| E-Mail |
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