| 초록 |
Drug delivery systems (DDS) have been explored as an option for treatment of diverse diseases. Various carriers including polymers, lipids and natural materials have been developed to enhance drug efficacy and minimalize side effect of drugs. However, diverse extra- or intracellular barriers such as non-specific interaction, the plasma/nuclear membrane, and the endo/lysosomes often reduce drug efficacy of DDS. Among them, the endo/lysosomes are one of the obstacles for developing effective DDS because almost nano-sized carriers use endocytosis pathways for cellular internalization and should be escaped from the endo/lysosomes to reach target subcellular organelles. Thus, the effectiveness and functions of new endosomolytic molecules and polymers using a model gene delivery system will be introduced. |
