| 초록 |
Arsenic trioxide (ATO) has expressed high cytotoxicity to various cancer cells and has been characterized by lower risk of recurrence and metastasis. However, ATO has some drawbacks, such as short half-life and dose-limiting toxicity. Herein, we develop PEG-P(L-DOPA) nanoparticle that formed Ni(II) arsenite complexes on the P(L-DOPA) core domain. The Ni(II) arsenite complexes would effectively improve the structural stability of PEG-P(L-DOPA) nanoparticle in an aqueous phase. The release of arsenite would be inhibited at physiological pH (7.4), whereas, at an endosomal pH (~5.0), the release of arsenite was triggered by ionization of the Ni(II) arsenite complexes. This nanoparticle containing Ni(II) arsenite complexes could efficiently deliver arsenites into the cells, thereby inducing apoptosis of cancer cells. |
