| 초록 |
Cancer cells with an elevated level of reactive oxygen species (ROS) are known to be vulnerable to induction of intracellular oxidative stress. Therefore, cancer treatment by enhancing intracellular ROS production may be an efficient approach. Herein, we aim to develop a Cu(II) arsenite-mineralized polymeric nanoparticle (CuAS-MNP) as a novel ROS amplifying anticancer agent. Upon endocytosis, the released AS from CuAS-MNP elevated the level of hydrogen peroxide (H2O2), and through the Fenton-like reaction, ionized Cu2+ ions catalyzed subsequently the conversion of H2O2 into highly toxic apoptosis-inducing hydroxyl radical (·OH). CuAs minerals maintained its dormant crystalline structure at physiological pH, whereas, at endosomal pH, the release of Cu2+ ions and AS are simultaneously triggered by ionization of the CuAS minerals. This mineralized nano-Fenton reactor would serve as a novel oxidative stress amplifying system for effective cancer therapy. |
