| 초록 |
CO2 utilization is an attractive approach as it allows the direct conversion of CO2 into valuable products. Direct carboxylation of heteroaromatic compounds is particularly attractive because the ubiquitous structural motifs of the corresponding carboxylic acids are commonly found in pharmaceuticals, organic materials, and commodity chemicals. C–H functionalization of electron-rich heteroaromatic compounds is often achieved by cooperative bimetallic catalytic systems that use either catalytic or stoichiometric silver additives. Despite several reports on the reactivity of silver salts capable of metalating electron-rich heteroaromatic compounds, a silver catalyst system for sp2 C–H carboxylation has not been reported to date. Herein, we report the Ag-catalyzed C–H carboxylation of thiophene derivatives. This new catalytic system involving a phosphine ligand and lithium tert-butoxide enables the direct carboxylation of thiophenes under mild reaction conditions. |
