| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Paclitaxel Delivery System Based on Self-Assembled Nanoparticles |
| 초록 |
Paclitaxel (PTX) is one of the most effective chemotherapeutic drugs used in many cancer treatment. However it is hard to apply in many diseases due to low solubility in water and physiological conditions. To enhance its solubility, we constructed self-assembled nanoparticles through host-guest chemistry between PTX and CD. It has less than 100 nm size of nano-sphere and form stable nano-assembly structure. It showed higher water solubility than PTX owing to hydrophilicity of CD. Furthermore, this inclusion complex showed enhanced antitumor effect than PTX. Finally, we developed self-assembled PTX-CD inclusion complex via host guest chemistry. This novel concept has the potential for further biomedical application of controllable drug delivery system. |
| 저자 |
장유나1, 남궁란1, 이병헌2, 김인산2, Allan S. Hoffman2, 김원종3
|
| 소속 |
1POSTECH, 2경북대, 3Washington Univ. |
| 키워드 |
Drug delivery system; Paclitaxel; β-Cyclodextrin; Nanoparticle
|
| E-Mail |
|
