| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
S-Nitrosoglutathione-Releasing Mineralized Nanoparticles Enhance Anticancer Activities of Arsenite by Reversing Drug Resistance |
| 초록 |
Multidrug resistance (MDR) is one of the biggest obstacles for successful therapy of cancers. Thus, overcoming drug resistance is a major challenge for cancer therapy. Of various mechanisms of resistance in tumor cells, we focus on MDR by overexpression of glutathione s-transferases (GSTs). If it is possible to suppress GSTs of MDR cancer cells, drug resistance would be reduced, and therapeutic efficacy of delivered drugs would increase. Herein, we propose a novel strategy to overcome resistance to arsenite by designing mineralized intracellular nanocarriers that simultaneously release a GST inhibitor (S-nitrosoglutathione (GSNO)) and arsenite. In acidic endosomal compartments (~pH 5.0), the mineral phase of the nanoparticles dissolved to release GSNO, which inactivated GSTs, thereby increasing cellular accumulation of apoptotic arsenite. Our mineralized nanoparticles may serve as an efficacious anticancer agent in terms of tumor resistance and selectivity. |
| 저자 |
황원태1, 이상천1, 정서영1, 이경태1, 민경현2, 이홍재1
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| 소속 |
1경희대, 2전북대 |
| 키워드 |
Nanoparticle; drug resistance; glutathione s-transferase
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| E-Mail |
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