| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Absorbable Fibrin Glue Formulated with PLGA Microparticles for Sustained Delivery of Anesthetic Drug, Bupivacaine |
| 초록 |
To control a post-operative pain, a local anesthetic drug is often injected at the site of interest. However, this bolus drug injection is limited in its short residence time, thereby low bioavailability of drug. To resolve this, we fabricated biodegradable microparticles loaded with bupivacaine and formulated them in fibrin glue. Bupivacaine hydrochloride-loaded microparticles were prepared by the O/W emulsion method. The drug loaded microparticles were then suspended in fibrin glue to give a formulation for actual application. we evaluated their in vitro drug release profile in pH 7.4 PBS. After a burst release of 38% on day, the drug was slowly released for more than 30 days. In vivo experiments were conducted using living rats. Our formulation revealed that the pain-relief efficacy could be prolonged for up to 20 days. |
| 저자 |
김세나1, 최병현2, 허범강1, 이승호1, 김현구2, 최영빈1
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| 소속 |
1서울대, 2고려대 |
| 키워드 |
Bupivacaine; Fibrin Glue; PLGA; Microparticles; Drug Delivery System
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| E-Mail |
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