| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Mucoadhesive Nanostructured Microparticles for Their Prolonged Retention in Gastrointestinal Tract to Increase the Bioavailability of Oral Drugs |
| 초록 |
Oral drug of poor bioavailability often needs multiple daily administrations to maintain a therapeutically effective level of systemic drug concentration, which is limited in an inconvenient regimen of drug therapy. In this sense, the carriers, which could stay in the gastrointestinal (GI) tract and also release drug in a sustained manner, would be useful. For this, we propose mucoadhesive, nanostructured microparticles as a potential oral-drug carrier in this work. Those functional microparticles herein possessed a high specific surface area originated from their nanostructure, hence improved mucoadhesion through a gastrointestinal (GI) tract. We examined the in vivo retention time of the microparticles in the GI tract after their oral administration in living rats in this study |
| 저자 |
박천권, 허범강, 김세나, 이승호, 김병휘, 김명훈, 박민, 홍혜림, 김가령, 최영빈
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| 소속 |
서울대 |
| 키워드 |
Mucoadhesion; nanostructured microparticle; specific surface area; gastrointestinal tract
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| E-Mail |
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