| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
Improvement on Solubility and Dissolution rate of Rivaroxaban by Supersaturatable Self-microemulsifying Drug Delivery System |
| 초록 |
Rivaroxaban is a potent selective oral direct factor Xa inhibitor, which has been shown poorly aqueous solubility and low bioavailability. The purpose of this study was to develop supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) for improving solubility and dissolution rate of rivaroxaban. An efficient self-microemulsifying carrier for rivaroxaban was selected and optimized using solubility testing and phase diagram construction. The formulations were characterized by assessing self-emulsification performance, droplet size, in vitro drug release and stability. Rivaroxaban has been shown high solubility in Labrafill m 2125, Tween 80 and tetraglycol. Overall, incorporation of hydrophilic polymer(Soluplus, PVP K 30 and Solutol HS 15) in SMEDDS resulted in improved solubility and dissolution rate compared to pure rivaroxaban. This study suggests that S-SMEDDS may be promising for enhancement on solubility and dissolution rate of rivaroxaban in the future development. |
| 저자 |
정형식, 이수환, 이예림, 이계원, 서민정, 최지원
|
| 소속 |
건양대 |
| 키워드 |
Rivaroxaban; S-SMEDDS; solubility; dissolution rate
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| E-Mail |
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