| 학회 | 한국고분자학회 |
| 학술대회 | 2003년 봄 (04/11 ~ 04/12, 연세대학교) |
| 권호 | 28권 1호, p.184 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Acylation behavior of glycol chitosan with succinic anhydride |
| 초록 | Chitin is a natural biopolymer that, with its derivative chitosan, has been represented as a biomaterial with considerable potential in wide ranging medical applications. There are some limitations in using chitosan as attained, for instance, the problem of water solubility. In order to use chitosan in various applications (i.e. drug carrier), chemical modifications are often necessary. Among the chemical modifications, acylation is the easy and effective method to obtain the water solubility and the novel functionality in chitosan which can be used for conjugation of drug, etc. Other researches on acylated chitosan, showed somewhat different results in the degree of substitutions and the selectiveness of N-acylation which were acylated even under almost the same condition. So we tried to clarify the above mentioned situation. In this study, using glycol chitosan instead of chitosan to obtain the water solubility, we acylated with varing the molar ratio of succinic anhydride, methanol content of solvent, which is known to be effective for selective N-acylation, and the reaction temperature. The resulting acylated chitosan was characterized with various techniques such as FT-IR, 1H-NMR, and Elemental analysis, etc. |
| 저자 | 이원범;박종래 |
| 소속 | 서울대 |
| 키워드 | Acylation; Chitosan |
