| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Low Molecular Weight Chitosan-Based Conjugate: A New Platform for Oral Delivery of Paclitaxel |
| 초록 |
A new platform for oral delivery of paclitaxel (PTX) was developed using a chemical conjugate system between PTX and low molecular weight chitosan (LMWC) having a narrow range of molecular weight (Mw). Three different Mws of chitosan (3k, 6k) were used to prepare the conjugates. The conjugates contained 10-20% of PTX in weight and showed greatly enhanced water solubility (＞ 1 mg/mL) compared to native PTX (＞ 0.01 mg/mL). In vitro cytotoxicity of the conjugates on murine lung carcinoma cells was evaluated by MTT assay, resulting in sight loss of cytotoxicity less than a fifth compared to that of PTX. When the conjugates (20 mg/kg based on PTX content) were administered to murine carcinoma bearing mice, the conjugate-treated groups showed significant inhibition of tumor growth, resulting in up to 69% in tumor mass relative to control (saline treatment). |
| 저자 |
이은혜, 이진주, 전상용
|
| 소속 |
광주과학기술원 |
| 키워드 |
paclitaxel; chitosan; oral delivery
|
| E-Mail |
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