| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Osteoinductive Hyaluronic Acid-Catechol Hydrogel to Enhance Bone Regeneration by Human Adipose-derived Stem Cells |
| 초록 |
Development of osteoinductive biomaterial scaffolds is critical for efficient bone formation following stem cell transplantation. Here, we report a catechol-functionalized hyaluronic acid (HA-catechol) hydrogel with improved biocompatibility compared to typical photopolymerized HA hydrogel. To improve osteoinductive property of HA-catechol hydrogel, the peptides derived from BMP-2 were incorporated into the HA-catechol hydrogel. BMP-2-incorporated HA-catechol hydrogel greatly enhanced in vitro osteogenic differentiation of human adipose-derived stem cells (hADSCs) in both osteogenic and nonosteogenic medium conditions. Finally, transplantation of hADSCs using BMP-2-HA-catechol hydrogel enhanced in vivo bone formation in a critical-sized calvarial bone defect. Acknowledgment: This work was supported by grants 2009-0083522 and 2013-Fostering Core Leaders of the Future Basic Science Program, NRF |
| 저자 |
양기석, 신지수, 이종승, 조승우
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| 소속 |
연세대 |
| 키워드 |
Hyaluronic Acid-Catechol Hydrogel; Human Adipose-derived Stem Cells; Bone Regeneration
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| E-Mail |
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