| 학회 |
한국공업화학회 |
| 학술대회 |
2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 |
25권 2호 |
| 발표분야 |
포스터-콜로이드·계면화학 |
| 제목 |
Zr-based metal-organic frameworks with ice-binding moiety for cell cryopreservation |
| 초록 |
Antifreeze proteins (AFPs) can be utilized in cryopreservation of cells, tissues, drugs, and foods. Metal-organic frameworks (MOFs) nanoparticles (NPs) can provide periodically arranged ice binding sites by modification of organic linkers, that can control ice crystal growth accurately. In this study, the zirconium (Zr) was adopted as a metal cluster which is well-dispersed and stable in aqueous phase. We explored the effect of MOF NPs size on antifreeze activity as the microcurvature of ice surface can be varied by MOF NPs attachment during recrystallization. The specific ice-binding moiety was introduced to acrylate-functionalized MOF NPs to enhance ice recrystallization inhibition. This work provides a strategy for generating the cost-efficient, mass-producible antifreezing nanoagents which can broaden its biological applications. |
| 저자 |
전나영1, 이지연1, 정인호2, 박현우3, 이창환2, 이희정3, 이은지1
|
| 소속 |
1광주과학기술원, 2서울아산병원, 3한국재료(연) |
| 키워드 |
Metal-organic framework (MOF); Self-Assembly; Cryopreservation
|
| E-Mail |
|
