| 초록 |
Eye drops as conventional ophthalmic delivery systems result in poor bioavailability and therapeutic responce because of lacrimal secretion and nasolacrinal drainage in eye. Recently, in situ gel formation has extensively been studied to enhance ocular bioavailability and duration of the drug. In previous study, ciprofloxacin was sustanedly released from the poloxamer-graft-hyaluronic acid(PL-g-HA) hydrogel due to the in situ gel formation of the copolymer and viscous properties of HA in vitro. In this study, we checked the possibility of tissue engineering oriented ophthalmic drug delivery system because the HA serves a critical role as a signaling molecule in cell motility, cell differentiation, wound healing, cancer metastasis and growth factor action. |
