| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
The role of silver nanoparticles in electrospun biodegradable nanofibrous scaffolds for tissue engineering |
| 초록 |
The increasing number and percentage of total joint infections with multiresistant bacteria makes an adequate prophylaxis against the organisms. The purpose of this study is to evaluate biodegradable nanofibrous scaffolds loaded with antimicrobial silver particles having a size of 520 nm. Antibacterial activity of biodegradable nanofibrous scaffolds against Staphylococcus aureus and Klebsiella pneumoniae was studied in vitro. Furthermore, the qualitative ongrowth of human osteoblasts was done to study in vitro cytotoxicity. The silver-containing nanofibrous scaffolds completely inhibited the proliferation of Staphylococcus aureus and Klebsiella pneumoniae. On the other hand, the silver-containing nanofibrous scaffolds used in this study did not show cytotoxicity. Therefore, it cound be say that the silver-containing nanofibrous scaffold has a potential to be used in total joint arthroplasty particularly due to its effect against multiresistant bacteria. |
| 저자 |
싱즐챠이, 채원표, 최문정, 백진영, 강인규
|
| 소속 |
경북대 |
| 키워드 |
nanofiber; silver; cytotoxicity; antibacterial
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| E-Mail |
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