| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 봄 (04/05 ~ 04/07, 대전컨벤션센터) |
| 권호 |
42권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Preparation and evaluation of nanofiber sheets as a drug carrier for controlled release |
| 초록 |
The electrospinning technology has been widely used as a method to manufacture nanofiber sheets (NS) for biomedical engineering. To advance a sustained dexamethasone (Dex) delivery, in this work, we used the biodegradable poly (ε-caprolactone-co-L-lactide) (PCLA) copolymer. PCLA copolymer was utilized to produce electrospun Dex-loaded NS using water-soluble Dex (Dex(s)) and water-insoluble Dex (Dex(b)). Then, interconnected fibrous structures were confirmed by SEM. The assessment of Dex(b) and Dex(s) release from Dex-NS showed an initial burst of Dex(b) at 1 day and, ever afterward, the release retained almost similar amounts of Dex(b) for up to 4 weeks, indicating no and little releasing of Dex(b). On the other hand, Dex(s)-NS exhibited little initial burst of Dex(s) and first order releasing profile from Dex-NS. In conclusion, Dex-NS exhibited the sustained Dex(s) releasing for prolonged action periods, as well as to induce biodegradation of the NS over a defined treatment period. |
| 저자 |
이진우, 이혜연, 박승훈, 박준영, 김재호, 민병현, 김문석
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| 소속 |
아주대 |
| 키워드 |
nanofiber sheet; drug delivery; electrospinning; dexamethasone
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| E-Mail |
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