| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Growth Factor-immobilized Biodegradable Polymer Scaffolds for Cartilage Regeneration |
| 초록 |
Polymer scaffolds with controlled release of growth factors may be effective for tissue regeneration. It is recognized that many growth factors and cytokines possess affinity for heparin. Heparin is recognized to have specific affinity with various polymers. In this study, polycaprolactone (PCL) scaffolds were fabricated by blending PCL with a small amount of Pluronic F127 by a melt-molding particulate-leaching method. The Pluronic F127 chains exposed onto the scaffold pore surfaces was used to bind heparin and the following growth factors (TGF-β2, BMP-7). The TGF-β2 and BMP-7 were shown to be effective for the differentiation of bone marrow- or fat-derived mesenchymal stem cells to chondrocytes and thus cartilage regeneration. Amounts of heparin and growth factor in the PCL/F127 scaffolds were quantified by Toluidine blue method using UV spectroscopy and by ELISA kit, respectively. The growth factor release behaviors from the growth factor-immobilized scaffolds were investigated. |
| 저자 |
임성묵1, 조광준1, 육순홍1, 임군일2, 이진호1
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| 소속 |
1한남대, 2동국대 |
| 키워드 |
Growth factor; polycaprolactone(PCL); Cartilage regeneration
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| E-Mail |
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