| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
의료용고분자 부문위원회 |
| 제목 |
TGF- β2/PD98059-Loaded Porous Scaffold to Enhance Chondrogenesis and Suppress Hypertrophy from Stem Cells |
| 초록 |
Many researchers believed that growth factor-immobilized 3D porous scaffolds may be a good alternative to enhance the cartilage regeneration using mesenchymal stem cells (MSCs). However, hypertrophy which leads to cartilage loss along the joint space and bone deposition is still remained as a critical limitation. In this study, we fabricated the poly(DL-lactic-co-glycolic acid) (PLGA)/Pluronic F127 scaffolds with PD98059 (bulk loading) and TGF-β2 (surface immobilization) to estimate their potential use as a polymeric matrix for suppression of hypertrophy and enhancement of chondrogenesis from MSCs. The release behaviors of PD98059 and TGF-β2 from the scaffold were quantified using the HPLC and ELISA kit, respectively. The in vitro and in vivo chondrogenesis and hypertrophy behaviors of MSCs in the scaffolds were also investigated. This work was supported by a grant from the National Research Foundation of Korea (Grant No. NRF-2009-0088234). |
| 저자 |
오은조1, 오세행1, 임군일2, 이진호1
|
| 소속 |
1한남대, 2동국대 |
| 키워드 |
PD98059; TGF- β2; Hypertrophy
|
| E-Mail |
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