| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | The effect of porous membrane on drug release from multi-coated bead |
| 초록 | Some Oral drug delivery systems are based on osmosis. Water in medium is diffused through the membrane, because of osmotic pressure.1 To improve release profile of nifedipine (ND) beads, water absorption force, bead size and membrane porosity are very important. So, we prepared for ND beads by fluidized bed coating.2,3 The obtained beads were coated with the membrane containing different excipients to form channels in membrane. Membrane porosity could be controlled by water soluble excipients such as HPC (hydroxypropylcellulose), HPMC (hydroxypropylmethylcellulose), PEG200 to improve drug release. Membrane containing HPC indicated less drug release than those of membrane containing HPMC. Because HPC has low solubility to water than that of HPMC. The excipients got out of membrane influenced glass transition temperature of membrane. And we confirmed by DSC. Fig. 1. The release profile of bead coated with different membrane Fig. 2. DSC of membrane using HPC binder before and after dissolution. Acknowledgement : This work was supported by KMOCIE (10016482). Reference 1. R.K. Verma, B. Mishra and S. Garg, Osmotically controlled oral drug delivery, Drug Dev. Ind. Pharm. 26, 695, (2000) 2. L. Liu, G. Khang, J.M. Rhee and H.B. Lee, Monolithic osmotic tablet system for nifedipine delivery, J. Control. Release 67, 309, (2000) 3. S.C. Jeong, S.K. Cheon, Y.H. Cho, M.S. Kim, B. Lee, G.Khang and H.B. Lee, The Effect of Bead Size and Drug Solubility on Drug Release from Osmotic Granule Delivery System for Nifedipine, Polymer (Korea), 29(3), 288, (2005) |
| 저자 | 정성찬1, 조영호2, 이봉1, 김문석3, 강길선2, 이해방3 |
| 소속 | 1부경대, 2전북대, 3한국화학(연) |
| 키워드 | osmotic granule; DDS; porous membrane |
