| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Synthesis and micellar characterization of triblock copolymers by using methoxy poly(ethylene glycol)-block-poly(caprolactone) diblock copolymers |
| 초록 | Micelles composed of amphiphilic block copolymers have been shown to possess significant potential as delivery systems providing several advantages when used as a drug delivery system for hydrophobic drugs. Typically, copolymer micelles of this type are less than 100 nm in diameter, leading to prolonged circulation and altered biodistribution of drug encapsulated within micelles. Recently, amphiphilic block copolymers, in particular poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) or Pluronics®, have been shown to chemosensitize drug-resistant cancer cell lines. In addition, the molecular structure, shape, and hydrophilicity of the polymer have great effects on the micelle properties. Diblock copolymers of methoxy poly(ethylene glycol)-block-poly(caprolactone) was synthesized and characterized in order to assess the potential of these copolymers as a micellar drug-delivery system. Synthesized diblock copolymers was a MePEG molecular weight of 2000 g/mol and PCL molecular weight of 900 g/mol. Accdrding to using MPEG-PCL diblock copolymer, we synthesized triblock copolymer, MPEG-PCL-PCL, MPEG-PCL-PLLA, and MPEG-PCL-PLGA by the ring-opening polymerization of using the hydroxyl group of MePEG as the initiator. Molecular weight of terminal type was 900 g/mol. The synthesized tiblock copolymers were characterized with 1H NMR, GPC, DSC, and XRD. The micellar characterization of MPEG-Polyester tiblock copolymers in an aqueous phase was carried out by using NMR, atomic force microscope(AFM), and fluorescence techniques. As the degree of polymerization of terminal types, we acquired critical micelle concentration (CMC) values and type and diameters of micellar core. This work has shown that triblock copolymers could be successfully synthesized using a ring opening polymerization. We suggest that these copolymers may be suitable micellar carriers of hydrophobic drug. Acknowledgement : This work was supported by MOCIE (10006921) Reference 1. Letchford Kevin , Zastre Jason , Liggins Richard , and Burt Helen, Synthesis and micellar characterization of short block length methoxy poly(ethylene glycol)-block-poly(caprolactone) diblock copolymers, Colloids and Surfaces B: Biointerfaces, 35, 81-91 (2004). 2. G. Khang, J. M. Rhee, J. S. Lee, and H. B. Lee, Polymer Sci. Tech., 12, 4 (2001). |
| 저자 | 조영호1, 정성찬2, 김문석3, 강길선1, 이해방3 |
| 소속 | 1전북대, 2부경대, 3한국화학(연) |
| 키워드 | ring-opening polymerization; critical micelle concentration |
