| 초록 |
Controlling morphological property of surface including various micropatterns can modulate cells' adhesion, proliferation, and alignment. However, the variation of depth between patterns impedes the cell-cell communication, threatening cells’ homeostasis. Here, we report a new approach for surface modification able to provide both spatial cell alignment and environment for intercellular communications using charged nanoparticles. We fabricated that the periodic patterns of a surface with different charges using photolithography and nanoparticle with charged ligands. The cells on the patterned surface aligned the lines of the pattern without geometrical variations. The surface fabricated by our approach can provide more enhanced environments to communicate via gap junctions than groove patterned surfaces. This strategy using the difference of charge density paves a new way to control the cell behavior on surfaces, providing a clue to regulate spatially physiologic processes. |
