| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
Energy-independentgene delivery mediated by mimics of cell-penetratingpeptides polymer |
| 초록 |
Cellpenetrating peptides (CPPs), a series of cationic that exert macromoleculartransduction across the membrane were identified. Since CPPs have an ability tomediate transfer of macromolecules across the cell membraneendocytosis-dependent processes, Those are used for intracellular delivery ofsmall molecules, proteins, and nucleic acid drugs. A class of bile acids (BAs)such as deoxycholic acid (DA) has an unusual structural feature in which two tothree hydrophilic hydroxyl groups face to the same direction and hydrophobicsteroidal hydrocarbons orient to the opposite direction. The structural featureis similar to the CPPs which may play an important role for the membrane fusionor permeabilization of the peptide. Herein, a molecular amphiphile (BA) and acationic polymer, polyethylenimine(PEI), one of the most widely used genecarriers were conjugated to mime the CPPs. |
| 저자 |
박채은, 임수연, 김다훤, LYU SIYAN, 황위보, 김병덕, 정준구, 신주화, 이지현, 유빈, 정지훈
|
| 소속 |
성균관대 |
| 키워드 |
gene delivery; polyplex; nano; systemic delivery
|
| E-Mail |
|
