| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
TGF-β1 coupled PLGA/Dexamethasone Scaffold for Cartilage Regeneration using Bone Marrow Mesenchymal Stem Cells |
| 초록 |
Bone marrow mesenchymal stem cells (BMSCs) are capable of differentiating into connective tissue-forming cell lineages. Known as an alternataive cell source to chondrocytes, many studies have utilized them for in vitro cartilage formation under an appropriate 3D environment equipped with bioactive cytokines. Transforming growth factor-beta (TGF-β1) and Dexamethasone (DEX) are of particular interest, because they are belived to enhance the chondrogenic differentiation of BMSCs in vitro. In the present work, We hypothesize that incorporation of TGF-β1 and DEX onto porous PLGA scaffold may be a suitable platform for the induction of chondrogenesis of BMSCs. Release of TGF-β1 and DEX would promote promote chondrogenesis compared to unmodified PLGA scaffold. Chondrogenic differentiation of BMSC was evaluation using histology, gene expression of collagen type II, Aggrecan, GAPDH, and Sox 9 |
| 저자 |
조경진1, 박귀덕1, 김익환2, 안광덕1, 한동근1
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| 소속 |
1한국과학기술(연), 2고려대 |
| 키워드 |
Functional PLGA scaffolds; Bone marrow mesenchymal stem cells; TGF-β1; Dexamethasone; Chondrogenesis
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| E-Mail |
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