| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Preparation of nano-emulsified paclitaxel for sustained release. |
| 초록 |
Purpose. To prepare nano-emulsion of paclitaxel by self micro emulsion drug delivery system(SMEDDS) and confirm the stability of nano-emulsified paclitaxel according to MPEG-PLGA diblock copolymers. Methods. Lactide and glicolide were added to MPEG dissolved in toluene under nitrogen, followed by the addition of stannous octoate in dried toluene. The stability of nano-emulsified paclitaxel was examined by shaking. Results. The polymerization gave MPEG-PCL diblock copolymers with the various ratios in MPEG and PLGA. Paclitaxel and MPGE-PLGA diblock copolymers were dissolved by solubilizers which were a mixture of tetraglycol, Cremophor ELP, and Labrasol. The droplet size distribution is comparatively narrow for all formulations. This indicated that stability of nano-emulsion strongly depended on the HLB values of MPEG-PLGA diblock copolymers. Conclusion. These results prove that the formulations tried in this study could be used as administration form of paclitaxel for clinical trials. |
| 저자 |
윤주용1, 조재송1, 김병수2, 오재민1, 김문석2, 강길선1, 이해방2
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| 소속 |
1전북대, 2한국화학(연) |
| 키워드 |
paclitaxel; SMEDDS; nano-emulsion; MPEG-PLGA
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| E-Mail |
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