| 초록 |
In this study, insulin-immobilized cadmium sulfide nanoparticles (ICSNPs) were prepared by a coupling reaction with mercaptoacetic acid-coated cadmium sulfide nanoparticles (CSNPs) followed by immobilization of amino-terminated PEG (PCSNPs) and subsequently with insulin. The surface properties of CSNPs and ICSNPs were characterized by XRD, UV, FT-IR, TEM and DLS. Finally, human fibroblasts were cultured in the presence of CSNPs, PCSNPs and ICSNPs to evaluate the cell proliferation and cytotoxicity. The higher cell growth was obtained in the presence of ICSNPs than that of PCSNPs and CSNPs. Furthermore, cell toxicity reduced considerably in the presence of ICSNPs compared to PCSNPs and CSNPs. |
