| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Tumor targeting effect of iron oxide nanoparticle-loaded nano-carriers |
| 초록 |
Generally, the physicochemical parameters (eg. size, shape, and mechanical property, etc) of nano-systems are important to meet a sufficient targeting efficiency and prolonged life time in vivo. In this study, we prepared an iron oxide nanoparticle (IONP) loaded functional nano-carrier with different loading contents to control the mechanical properties of the system, and compared the effects of tumor targeting and imaging with loading contents of IONP. The mechanical properties of nano-carriers were successfully controlled and affected the magnetic resonance contrast effect, cellular uptake, and bio-distribution of the system. Interestingly, the nano-carriers with more rigid characteristics showed lower tumor targeting efficiency than soft and flexible nano-carriers. Acknowledgement: partial support by the NRF funded MEST of Korea(R15-2008-006-02002-0), and WCU program at GIST, MEST of Korea(R31-2008-000-10026-0). |
| 저자 |
최원일1, 김만세2, 김자영1, 허선우3, 정용연3, 김영하4, 태기융5
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| 소속 |
1광주과학기술원 신소재공학부, 2광주과학기술원 광응용물리학과, 3전남대, 4중앙대, 5광주과학기술원 신소재공학부 및 광응용물리학과 |
| 키워드 |
iron oxide nanoparticles; nano-carriers; mechanical property; magnetic resonance cancer imaging
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| E-Mail |
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