| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
(콜로이드.계면화학) 기능형 콜로이드 입자의 제작과 응용 기술 |
| 제목 |
Mutually Insoluble PEG-Based Microcapsule: Biocompatible and Multicomponent Encapsulation |
| 초록 |
Despite the recent development in various materials capable of encapsulating therapeutics and biomolecules for biomedical applications, there exist limited reports on multicomponent encapsulation in biocompatible microcapsules. In this work, we utilize the molecular weight dependent solubility of poly (ethylene glycol) diacrylate (PEGDA) to achieve direct encapsulation of both hydrophilic and hydrophobic cargoes in PEG-based microcapsules. We show that PEGDA 250, which has three PEG repeat units and two acrylate groups, is mutually insoluble in both water and oil unlike higher molecular weight analogues. By using PEGDA 250 as the middle phase in W/PEGDA250/W double emulsion drops, we demonstrate that PEG-based microcapsules allow simultaneous encapsulation of both hydrophilic and hydrophobic cargoes. We further confirm the validity of this approach by demonstrating that complex biomolecule such as protein can be effectively encapsulated within these PEG-based microcapsules. |
| 저자 |
남창우1, 윤종선1, 류상아1, 최창형2, 이효민1
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| 소속 |
1포항공과대, 2대구한의대 |
| 키워드 |
poly(ethylene glycol) diacrylate; encapsulation; microcapsules; droplet-microfluidics
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| E-Mail |
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