| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Sequestering ATP inside Mitochondria by Nucleopeptide inducing Cancer Cell death |
| 초록 |
Adenosine triphosphate (ATP) has important roles in cellular processes such as cellular respiration and metabolism. Cancer cells have higher concentration of ATP compared to normal cells. By removing ATP inside cancer cells, it can result apoptosis. Herein, we developed selective cancer treatment by sequestration and assemblies of ATP with nucleopeptide (NP). NP has nucleobase which interact with adenine and positively charged and hydrophobic peptides which have mitochondria targeting group and self-assemble in water. NP exhibits higher binding affinity with ATP by electrostatic interaction resulting in large complex and assemblies with ATP compared to ADP. To enhance selectivity towards cancer cells, NP-ADP having nanometer-sized micelles accumulates inside cancer cells leading to formation of NP-ATP with higher binding affinity. Sequestration of ATP and large assemblies of NP-ATP cause severe effects such as the metabolic process of ATP and stress by structures towards cancer cells. |
| 저자 |
최후연1, 유자형2
|
| 소속 |
1UNIST(Ulsan National Institute of Science and Technology), 2울산과학기술원 |
| 키워드 |
sellf-assembly; ATP; nucleopeptide; anticancer therapy
|
| E-Mail |
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