| 학회 |
한국고분자학회 |
| 학술대회 |
2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 |
27권 1호, p.274 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis and characterization of biodegradable star-shaped PLGA-PEG block copolymer |
| 초록 |
Temperature sensitive polymers for drug delivery system have been studied intensively for the past two decades. In this study, biodegradable star-shaped poly((D,L-lactide-co-glycolide)-block-ethylene glycol) (star PLGA-PEG) of which PEG block molecular weight was 550 were synthesized and characterized by 1H-NMR, 13C-NMR and GPC. Star PLGA were synthesized by bulk ring opening polymerization of D,L-lactide and glycolide on nontoxic glycerol. Hydroxyl end group of mono methoxy PEG (MW = 550) were carboxylated and coupled with the hydroxyl terminal group of star-PLGA. The temperature dependent sol-gel transition behaviors of block copolymers in aqueous solution were investigated by tube inversion method. The effective diameter of micelle of star PLGA-PEG block copolymers in aqueous solution was measured by dynamic light scattering with varying temperature. |
| 저자 |
한보령1, 박상엽2, 한동근*3, 김성철4
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| 소속 |
1한국과학기술원, 2기능성고분자신소재연구센터, 3*한국과학기술(연), 4생체재료연구센터 |
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