화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2008년 가을 (10/09 ~ 10/10, 일산킨텍스)
권호 33권 2호
발표분야 기능성 고분자
제목 Hyaluronic acid-lipoic acid graft copolymer for functional cosmetics
초록 Hyaluronic acid (HA) is a biodegradable, biocompatible and natural linear polysaccharide with a broad molecular weight range from 100 to 10,000,000 Da. It is used widely in the pharmaceutical field. Lipoic acid (LA) is multifunctional antioxidant. It helps in the regeneration of exogenous and endogenous anti-oxidants such as Vitamin C, Vitamin E. Hydrophilic HA was conjugated with hydrophobic LA to form graft copolymer. The graft copolymer of HA-LA could form self-assembled nanoparticles in aqueous solution. The CAC was ca. 1Χ10-4 measured by fluorescence spectroscopy. Their sizes were ca. 170nm measured by TEM and DLS. Vitamin could be loaded in the hydrophobic core of nanoparticles by the dialysis method. The loading efficiency and the release profiles of the HA-LA nanoparticles were measured by HPLC.
저자 이선영, 홍인림, 김영진
소속 충남대
키워드 hyaluronic acid; lipoic acid; antioxidant; vitamin
E-Mail kimyj@cnu.ac.kr