| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 |
29권 1호, p.17 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis of Dendritic Hybrid Polymer for the Delivery of Bioactive Agents |
| 초록 |
Dendritic hybrid consists of a linear polymer and dendritic units chemically conjugated at each chain end of linear polymers. It is expected that the dendritic hybrid shows a tendency to form a unimolecular micelle and has a precise control over the size by changing the degree of polymerization of the linear polymer part as well as the generation number of dendritic part. Unimolecular micelle leads to the increased stability in the blood stream compared with micelles due to the absence of critical micelle concentration. Diblock and 4-arm star copolymers consisting of linear and hyperbranched blocks were synthesized. Diblock copolymers with PEG-based hydrophilic block and hydrophobic poly(THF) block were self-associated in aqueous solution to form a micellar structure above critical micelle concentration(CMC). 4-Arm star copolymers did not show CMC and displayed the characteristics of unimolecular micelle. Unimolecular micelle leads to the increased stability in the blood stream compared with polymeric micelles due to the absence of CMC. Pyrene loading efficiency to 4-arm star copolymers was higher than that of diblock copolymers. 4-Arm star copolymers had sustained release profile in comparison to diblock copolymers. |
| 저자 |
안철희, 문성호
|
| 소속 |
서울대 |
| 키워드 |
drug delivery system; dendritic hybrid; unimolecular micelle
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| E-Mail |
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