| 학회 |
한국고분자학회 |
| 학술대회 |
2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 |
29권 1호, p.193 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Dendritic Hybrid Polymer as a Novel Carrier of Bioactive Agents |
| 초록 |
Diblock and 4-arm star copolymers consisting of linear and hyperbranched blocks were synthesized. Diblock copolymers with PEG-based hydrophilic block and hydrophobic poly(THF) block were self-associated in aqueous solution to form a micellar structure above critical micelle concentration(CMC). 4-Arm star copolymers did not show CMC and displayed the characteristics of unimolecular micelle. Unimolecular micelle leads to the increased stability in the blood stream compared with polymeric micelles due to the absence of CMC. The sizes of synthesized diblock and 4-arm star copolymers measured by dynamic light scattering in water were 120nm and 92nm. Pyrene loading efficiency to 4-arm star copolymers was 46%, 11% higher than that of diblock copolymers. 4-Arm star copolymers had sustained release profile in comparison to diblock copolymers. |
| 저자 |
문성호, 안철희
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| 소속 |
서울대 |
| 키워드 |
dendritic hybrid; 4-arm star copolymers; unimolecular micelle;
|
| E-Mail |
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