| 초록 |
Synthetic polypeptides have been widely studied as antibiotics. Among them, copolypeptide, which comprises both hydrophilic and hydrophobic parts have been considered as biocompatible antibiotics since they are and less toxic than the conventional one and reduce the antibiotic resistance. The copolypeptides can be easily synthesize via ring-opening polymerization of N-carboxyanhydride with a variety of architectures. First, copolypeptide with lysine and phenylalanine moieties was prepared, followed by guanidinylation of lysine to generate copolypeptide with arginine and phenylalanine moieties. The resultant polypeptide structures were confirmed using proton nuclear magnetic resonance and Fourier transform infrared spectroscopy. The optical density value of the bacterial suspension was measured at a wavelength of 600 nm using UV-Vis spectroscopy. |
