| 초록 |
Antibiotics are being developed worldwide to treat pathogenic microorganisms, especially resistant bacteria. However, bacteria are inherently resistant to certain antibiotics also get resistance to antibiotics. In addition, they could not overcome problems such as side effects and drug abuse. To overcome these problems, various antibacterial peptides and nanoparticles are being developed. But it is not a fundamental solution. To overcome this, we have developed nano-lipid drill nanoparticles (LD-NPs) using biocompatible albumin and lipid. These nano-antibiotics are a new concept that effectively induces lysis by breaking the structure by causing changes in cell membranes and changes in cell wall tension due to the difference in size between cells and bacteria and prevents resistance by not touching the central dogma. We demonstrate that these LD-NPs mechanisms are excellent antimicrobial agents that selectively kill a variety of bacteria. |
