| 초록 |
We present a facile method to prepare Europium-arsenite-loaded polymeric nanoparticles as a fluorescent delivery platform for an inorganic antineoplastic agent, arsenic trioxide. To this end, a series of PAA/PEG-based double-hydrophilic block-copolymers were self-assembled into a core/shell-type nanoparticles via polyvalent chelation with Eu(III) ions, which can then be employed as a nanoscale template for arsenite (AsO33-) incorporation. The initial EuIII-chelated nanoparticles exhibited a highly enhanced fluorescent property, while the subsequent arsenite incorporation as an insoluble EuIIIAsO3 complex further allows for the selective release of arsenite pharmacophore under acidic condition. In this presentation, the chemical structures of EuIIIAsO3-loaded nanoparticles and the relevant physicochemical properties will be discussed. |
