| 초록 |
Development of adhesives used for medical purposes requires adhesiveness in wet environments. A similar catechol derivative called gallol, which found in various plants, shows excellent wet-resistant adhesive properties. Herein, we developed an entirely new class of medicinal materials utilizing gallol groups. The key molecule is tannic acid containing many gallol groups, which shows highly strong bioadhesion based on affinity with various biomacromolecules. The first formulation of the gallolic adhesive is produced by intermolecular hydrogen bonding between tannic acid (TA) and poly(ethylene glycol) (PEG) called TAPE. The second formulation of the adhesive is a hydrogel by intermolecular hydrogen bonding between TA and DNA, called TNA gels. Widespread use of these formulations is anticipated in various medical and pharmaceutical applications because of its scalability, tissue adhesion, and facile preparation. |
