| 초록 |
Bio material scaffold are great importance for tissue engineering and orthopedic implant owing to they enable support biological property and biomechanical property for surrounding bone. These biomaterial scaffolds require good porous structure such as porosity, pore size and good interconnectivity with pores. Recently ceramic, polymer and metal have been extensively used as bio material for fabricating porous scaffold to promote bone ingrowth in to pore. We herein demonstrate a novel, versatile approach to produce biomimetic porous ceramics with a continuously gradient porous structure using three-dimensional extrusion of a bilayered ceramic-camphene mixture/pure camphene feedrod. In this study, bi-layered feed rod comprised of the ceramic/camphene mixtures and law contents of ceramic or pure camphene used as the lower and upper part feed rod. Bi-layered feed rod could be gradually extruded with core/shell structure because of the wall slip phenomenon. This enabled the formation of green filaments comprised of a camphene core surrounded by a ceramic/camphene shell, where the core/shell thickness ratio increased gradually as extrusion proceeded. Biphasic calcium phosphate (BCP) ceramics with a gradient porous structure could be successfully produced by three-dimensionally depositing the extruded filaments layer by-layer. We evaluated gradient micro structure with produced gradient porous BCP ceramic scaffold by scanning electron microscopy (SEM) and Micro CT. |
