| 초록 |
Cryogels are highly interconnected macroporous scaffolds produced by freeze-thawing and freeze-drying. Cryogels have been widely utilized as a scaffold for tissue regeneration due to improved mechanical properties and macroporous structure. In particular, many types of cryogels releasing various bioactive molecules have been developed for facilitated tissue regeneration. Among them, calcium ion (Ca2+) and oxygen (O2) are well known to enhance osteogenesis and angiogenesis, respectively. Herein, we develop Ca2+- and O2-releasing cryogels via calcium peroxide (CaO2)-mediated crosslinking. We demonstrate that the cryogels exhibit an initial burst release of O2 within 2 days and sustained release of Ca2+ for 28 days depending on hydrogel compositions. The cryogels show facilitated osteogenic cell proliferation by Ca2+ released from cryogels. In sum, our CaO2-mediated gelatin cryogels with controlled release of Ca2+ and O2 can utilize as a promising material for bone regeneration. |
