| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Multi-stimuli Responsive Elastin-Calmodulin Diblock Polypeptides for Dynamic Drug Delivery Systems |
| 초록 |
Protein block copolymer-based nanostructures have gained increased interest for a variety of biomedical applications because of easy control over amino acid sequence and block length and facile introduction of specific biological domains with stimuli-responsiveness at genetic level. We report herein molecular design, expression and purification of multi-responsive elastin-based polypeptide (EBP)-calmodulin (CalM) diblock polypeptides and characterization of thermal- and ligand responsiveness of the EBP and CalM block. Temperature-triggered self-assembled micelles of the EBP-CalM diblock polypeptides were formed via physical crosslinking due to thermal responsiveness of EBPs, and their micellar structures were affected by calcium and ligand. These multi-stimuli responsive EBP-CalM diblock polypeptides which would allow stimuli-triggered drug release kinetics are useful for dynamic drug delivery systems. |
| 저자 |
임동우1, 강민정2, 이재상3
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| 소속 |
1Department of Bionanotechnology, 2Hanyang Univ., 3ERICA Campus/Department of Bionano Engineering |
| 키워드 |
Elastin; Calmodulin; Diblock polypeptides; Stimuli-responsiveness; Self-assembly
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| E-Mail |
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