| 초록 |
In recent years, carboxymethyl cellulose (CMC) based hydrogels have immensely gained interest in biomedical applications. In general, CMC based hydrogels have been developed by physical crosslinking. To circumvent this issue, we designed a promising chemical crosslinking method to synthesize the norbornene-functionalized CMC based hydrogels via click chemistry. For this purpose, a redox- responsive, water soluble di-tetrazine terminated di-selenide di-polyethylene glycol (DSe-DPEG-DTz) crosslinker was employed to crosslink the norbornene with tetrazine (Nb-Tz). The inverse electron demand Diels Alder reaction between CMC-Nb to DSe-DPEG-DTz, producing N2 gas, which, in turn, led to generate in-situ porosity in hydrogel structure. The study showed that crosslinker proportion and porosity plays a vital role to increase the drug release. We envision that the formed hydrogels can offer versatility in tumor targeting drug delivery with rapid release of the drugs. |
