| 초록 |
A detailed understanding of the biophysical features that affect cell adhesion, growth and development is important guiding the design of biomimetic scaffolds. Currently, there are number of approaches to develop biomimetic tissue remodeling in vitro that allow for control cell adhesion, the physical properties of the matrix, and the spatial distribution of geometrical cue. In this study, we present a simple method to create transplantable, uni-directionally aligned muscle cell patches which contains a mixture of muscle mononuclear cells, including the progeny of satellite cells and other potential resident myogenic cells. Furthermore, we have demonstrated that biodegradable nanopatterned PLGA patches not only directed uniform alignment in vitro, but also enhanced myogenic myofibers with nanopatterned patch as compared to flat patches demonstrates that the transplantable muscle cell patch can be suitable utilized for treating chronic and acute muscle diseases or injuries. |
